Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels
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چکیده
منابع مشابه
Extracellular Domain N-Glycosylation Controls Human Thrombopoietin Receptor Cell Surface Levels
The thrombopoietin receptor (TpoR) is a type I transmembrane protein that mediates the signaling functions of thrombopoietin (Tpo) in regulating megakaryocyte differentiation, platelet formation, and hematopoietic stem cell renewal. We probed the role of each of the four extracellular domain putative N-glycosylation sites for cell surface localization and function of the receptor. Single N-glyc...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2011
ISSN: 1664-2392
DOI: 10.3389/fendo.2011.00071